The autoimmune disease is now the most common disease among the dog breeders and also people in the veterinary community. The symptoms of dog autoimmune disease vary based on the place of the immune complexes. The immune system is the biggest defense system of antibodies, white blood cells, and other elements to combat off foreign bodies and infections.
There are several types of autoimmune diseases and among them, Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease that affects several systems in the body. You can check the site http://www.petmd.com/dog/conditions/endocrine/c_dg_lupus_erythematosus to know more about them.
The immune system has the ability to detect its own cells and foreign invaders by markers available on the every cell surface in the body. This ability detects skin grafts, blood transfusions, organ transplants. Like other systems in the body, the immune system fails either by doing its functions too well or not doing its work.
Autoimmune disease is a type of failure of the immune system. In this disease, the body loses its ability to identify the self-marker and it started to attack and decline the own body cells like foreign. One certain tissue type, including red blood cells will be defeated or it results in generalized illness like systemic illness.
Till now, the reason for the autoimmune system cause is not identified. It is a serious disease and the majority of the dogs affected by this disease have a serious illness or die in worst situations. Secondly, many autoimmune diseases are treated with high doses of immunosuppressive drugs or corticosteroids to reduce the response of the immune system.
Autoimmune diseases in the skin are rare and also a diagnosis of this disease is tough. A general veterinarian practitioner may come across only a couple of cases with this disease. Immunofluorescent staining or skin biopsy is mandatory to diagnose the diseases and prognosis for recovery from the system may differ. “Pemphigus complex” is a group of autoimmune skin disorders of four systems including ulcers, vesicles, erosions, and bullae.
The common example of multi-systemic autoimmune disease is SLE or Systemic lupus erythematosus. It is also referred as “great imitator” since it has the potential to mimic any other disease. The symptoms of SLE are persistent and also cyclic. One of the crucial signs of this disease is an unpredictable fever that never responds to any antibiotics.
Other two organs affected by SLE are Polymyositis that affects the several muscle groups causes muscle wasting, pain, fever, and also changes in the attitude of the dog. Glomerulus affects the kidney function that leads to a condition called glomerulonephritis. It results in loss of protein I the urine and finally failure of the kidney.
Complete blood count, serum chemistry analysis are the basic things in diagnosing the above diseases. In Splenectomy, the spleen will be eliminated using the surgical procedure and it is suggested by a veterinarian for nonresponsive cases. It is advantages for the dogs because of a couple of reasons like important organ responsible for the damages is removed and fewer antibodies count are produced against RBC.